A delayed reaction to oxaliplatin.

A 64-year-old man who was receiving chemotherapy for gastric cancer with liver metastases was referred to our department for an allergy workup after experiencing a skin reaction. The chemotherapy regimen comprised taxotere, oxaliplatin, and 5uorouracil (5-FU) (combined with calcium folinate) followed by abundant intravenous hydration. Each cycle was administered in combination with a standard preparation containing ondansetron and methylprednisolone succinate. The patient experienced no problems during the rst 6 cycles of treatment. However, approximately 8 hours after the beginning of the seventh cycle, he developed a pruritic polymorphous maculopapular rash, mainly on the upper and lower limbs. No associated systemic manifestations were observed. Antihistamines and corticosteroids were administered immediately, and the rash resolved within 72 hours. The same reaction occurred 2 weeks after this episode, while the patient was receiving his eighth cycle of chemotherapy.